Harrison Ford and Brendan Fraser star in this true story of the power of love and faith against impossible odds. "There were plenty of times when the science was tough and the business was tough and I didn't want to be away from the family," recalls John. Director Jon Erwin discusses his inspiration for the film and how history might be repeating itself today. John Crowley and his wife Aileen are a Portland couple with two of their three children suffering from Pompe disease, a genetic anomaly that typically kills most children before their tenth birthdays. The movie also fails to effectively tug on our heartstrings. ?s indomitable will during World War II, saying, "Never, never, never quit.". "[13] Metacritic, which assigns a weighted average score out of 0100 reviews from film critics, has a rating score of 45 based on 33 reviews. In Extraordinary Measures Brendan Fraser and Keri Russell play the parents of three children, two of whom suffer from Pompe disease, a genetic disorder which has them confined to wheelchairs and which will kill them in short order. Researchers will select six children between the ages of 3 and 16 who have been diagnosed with Pompe disease and depend on ventilators to breathe, even with enzyme replacement therapy. Extraordinary Measures. (Or alternately, that you cant see past the stereotyped version of your own bailiwick.) This has been a very long process. Henceforth, more than 1000 infants born worldwide every year with Pompe disease will no longer face the prospect of death before reaching their first birthday for lack of a treatment for the condition. Fate and determination push idealistic father, John Crowley (Brendan Fraser) into joining forces with reclusive medical researcher, Dr. Robert Stonehill (Harrison Ford). Review aggregation website Rotten Tomatoes gives the film an approval rating of 29% based on reviews from 142 critics and an average rating of 4.88 out of 10. Ford is an entertainingly irascible scene-thief, but knowing hes just there to spice things up throws seeds of doubt into every moment of the film, undermining and distracting from Crowleys real-life struggles. Details have been dramatized for Extraordinary Measures. to remind us of the stakes. Or take Courtney B. Vance, completely wasted as another father with Pompe children; he literally has three scenes with dialogue amounting to "Here's a check I have two kids with Pompe Thanks for everything you're doing." "The Cure: How a Father Raised $100 Millionand Bucked the Medical Establishmentin a Quest to Save His Children," "Extraordinary Measures" follows Oregonian marketing executive John Crowley's (Fraser . Is "Extraordinary Measures" based on a book? Unfortunately, this advice comes too late for the new subsidiary CBS Films, which is launching its theatrical endeavors with the disease-of-the-week drama Extraordinary Measures. The film chronicles the couple's inspirational battle to find a cure for the terrible disease that affects their children. "She looked at me kinda gave me a thumbs-up then threw her arms around me," says John. Together, this unlikely pair face impossible odds as they battle the entire medical establishment and time itself to find a cure before its too late. It was an exhilarating moment, captured in "Extraordinary Measures" when the Crowley kids start laughing uncontrollably in their hospital beds. I noticed some improvement in mobility right after the first few treatments, says Griffin, who walks short distances, but largely relies on an electric scooter. The family spent every waking moment researching the disease. Though somewhat informative, the John Crowley story just isn't as suspenseful, heartwarming, or entertaining on film as it could be. Release . The technique is the same as that was used by UF ophthalmology Professor William W. Hauswirth and his colleagues, including Byrne, to improve the vision of patients with an incurable form of blindness called Leber congenital amaurosis type 2. Therapeutic Accelerator Initiative: In consultation with pharmaceutical and academic researchers specializing in biomarkers, imaging, and trial-readiness, we design and implement projects through commercial research companies and academic labs to solve key gaps inherent in FSHD. Myozyme, a drug developed for treating Pompe disease, was simultaneously approved for sale by the US Food and Drug Administration and the European Medicines Agency. Anything to show instead of tell would have helped. Inspired by the book The Cure by Pulitzer Prize Winning Writer Greeta Anand. What sustains it for people like the Crowleys? Also starring Golden Globe winner Kerri Russell, Extraordinary Measures is a true story of the power of love and faith against impossible odds. Director Tom Vaughan Writers Robert Nelson Jacobs Geeta Anand (book "The Cure: How a Father Raised $100 Million - And Bucked the Medical Establishment - in a Quest to Save His Children") Stars The film is based on the true story of John and Aileen Crowley, whose children have Pompe's disease. (for thematic material, language, and a mild suggestive moment). The Crowleys were told the grim news that 15-month-old Megan had a rare muscle-wasting condition, Pompe disease. A 2010 movie Based on a True Story and the book "The Cure" about John Crowley whose dedication to saving his two children from a genetic disease named Pompe results in him becoming a driving force in the development of an enzyme therapy. We may earn a commission from links on this page. John Crowley?a>? . Ultimately the company was purchased by Genzyme and an intravenous enzyme replacement drug was developed. Trailer. [5], In the film, the children are 9 and 7 years old. The site's general consensus is, "Despite a timely topic and a pair of heavyweight leads, Extraordinary Measures never feels like much more than a made-for-TV tearjerker. The "suggestive moment" involves a very brief scene when the Crowleys' personal nurse interrupts them during a moment of intimacy; though nothing is shown and it's intended for laughs, it's completely extraneous. There's an inordinate amount of profanity (including misuse of Christ's name) for a movie that might otherwise have been deemed family-friendly or appropriate for an elementary classroom. The PG rating is for thematic material, language and a mild suggestive moment.Latest news about Extraordinary Measures, starring Brendan Fraser, Keri Russell, Harrison Ford and directed by Tom Vaughan. Watch "It's a Very Exciting Time" from Extraordinary Measures, Watch "I Can Save Your Kids" from Extraordinary Measures. Extraordinary Measures would seem to have everything going for it: A touching story (based on the best-selling book The Cure) inspired by true events about a father's great lengths to save his kids' lives. Conversions credited to women evangelists sharing the good news one-on-one in conversations. She received several treatments as part of the final clinical trial and then became the first patient to receive the treatment on a commercial basis. [14] Audiences polled by CinemaScore gave the film an average grade of "A-" on an A+ to F scale. "[16] The New York Times' A. O. Scott said in his review: "The startling thing about Extraordinary Measures is not that it moves you. As anyone with an understanding of "orphan drugs" and the pharmaceutical industry knows, miracle cures don't simply develop overnight. Brendan Fraser plays John, Keri Russell plays his wife Aileen and Harrison Ford is Dr. Robert Stonehill, the man . "But I had a lot of confidence in my husband. But even with Ford, Extraordinary Measures reads like little more than a dramatized timeline. It was the first film produced by CBS Films, the film division of CBS Corporation, who released the film on January 22, 2010. "[17], Ramona Bates MD, writing for the health news organisation, EmaxHealth, stated that the film brings attention to Pompe disease. Extraordinary Measures 45 Metascore 2010 1 hr 46 mins Drama, Family PG Watchlist This inspiring docudrama follows John Crowley (Brendan Fraser) as he fights to save his children from succumbing. Early on, a doctor tells Crowley that the imminent death of his daughter could be seen as a blessingan end to her suffering. A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder.A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder.A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder. That vector is the adeno-associated virus, or AAV, that most humans already carry. In many areas of medicine, a combination of treatments is used to benefit the patient, and we hope the gene therapy approach will work in the same way.. John is driven to find a cure for his kids. The exception to that last comes in the form of Extraordinary Measures executive producer Harrison Ford, co-starring as a crotchety, eccentric University Of Nebraska researcher whose theories make Crowleys task possible, but whose recalcitrance and flakiness put up constant barriers. Additional studies by faculty researchers Shelley Collins, Cathryn Mah, David Fuller, Paul Reier and Danny Martin coordinated by advanced practice nurse Lee Ann Lawson will evaluate the patients development and rehabilitation potentials. Critics Consensus: Despite a timely topic and a pair of heavyweight leads, Extraordinary Measures never feels like much more than a made-for-TV tearjerker. [11] According to Roger Ebert's review, the character is based on Yuan-Tsong Chen,[6] a scientist and researcher from Duke University[12] who collaborated with Genzyme in producing Myozyme, the drug which received FDA approval. A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder.A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder.A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder. Thats where Crowleys children, Megan and Patrick, were in 2000 when he left his job at Bristol-Myers Squibb to lead the start-up company Novazyme. Also starring Golden Globe winner Kerri Russell, Extraordinary Measures is a true story of the power of love and faith against impossible odds. Also starring Kerri Russell, Extraordinary Measures is a true story of the power of love and faith against impossible odds. Fate and determination push idealistic father, John Crowley (Brendan Fraser, The Mummy) into joining forces with reclusive medical researcher, Dr. Robert Stonehill (Academy Award nominee Harrison Ford, Best Actor in a leading role, Witness, 1985). "I have a tiny little plaque on my desk which my mom gave me the week I started that tiny company. Less than a year after delivering the Class Day address at his HBS . Genzyme claims that Dr. Robert Stonehill's character is based upon scientist and researcher William Canfield,[10] who founded Novazyme. Eventually the terrible strain on their vital organs would claim their lives. Studies have given us encouraging evidence that gene therapy for some very devastating diseases is a realistic possibility, Byrne says. The gene therapy vectors meet U.S. Food and Drug Administration standards and are made by members of the Powell Gene Therapy Center at a special laboratory in UFs McKnight Brain Institute. You're going to live to be an old lady!". [8] Novazyme was developing a protein therapeutic, with several biological patents pending, to treat Pompe Disease, when it was bought by Genzyme. ReadMore , An aspect that is often overlooked during drug development is a cost-benefit analysis of a therapeutic treatment. John and Aileen raise money to help Stonehill's research and the required clinical trials. 1h 46m. (Keri Russell plays Aileen.) John learns of some promising research by a university scientist, Dr. Robert Stonehill, played by Harrison Ford. Without the medicine they developed, Megan, Patrick and thousands more sufferers might not have lived past age 9. What does he mean? It's also a movie that relies heavily on business and science jargon without delving deeply to make the dialogue interesting or informative. 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