The data can be made publicly available on reasonable request. Blood 2008;111:504-16. Reproducibility of radiomics for deciphering tumor phenotype with imaging. Bethesda, MD 20894, Web Policies Avigdor A, Bulvik S, Levi I, Dann EJ, Shemtov N, Perez-Avraham G. Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A. https://doi.org/10.1097/RLU.0000000000002732 (2019). Feature papers represent the most advanced research with significant potential for high impact in the field. Hodgkin lymphoma (HL) is one of the most common cancer types in young adults with the incidence peaking in people in their 20s. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. ; Mikhaeel, N.G. Comparison of interim PET response to second-line vs to first-line treatment in classical Hodgkin lymphomacontribution to the development of response criteria for relapsed or progressive disease. Med. Oncol. PET/CT mediastinal and liver FDG uptake: Effects of biological and procedural factors. 1 None of the 8 patients with a Deauville score of 3 at PET-2 scanning relapsed, but 1 of the 3 patients with a Deauville score of 4 eventually relapsed. ; Zucca, E.; Lister, T.A. However, NCCN imaging guidelines for lymphoma surveillance state that it is acceptable to perform chest radiography or CT of the chest every six to 12 months for the first two years and then yearly for the next three to five years posttreatment.41 Surveillance imaging with PET-CT scans following complete remission is not recommended.40,41 Disease marker research is ongoing, examining minimal residual disease measurements, a polymerase chain reactionbased method that looks at identifying tumor-specific DNA sequences.41, All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later.44 Patients receiving antiB-cell antibodies should not receive annual influenza vaccination, and administration of live vaccines is contraindicated during chemotherapy. those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). The left row shows the AUCs of Scanner A, and the right row the AUCs of Scanner B. Mol. Lymphoma represents a heterogeneous group of malignant neoplasms of lymphocytes, which can involve lymphatic tissue, bone marrow, or extranodal sites. Northwestern University, Evanston, Illinois. Editors select a small number of articles recently published in the journal that they believe will be particularly J. Nucl. The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. Imaging Biol. In the meantime, to ensure continued support, we are displaying the site without styles This cutoff is of the highest relevance7,8. WebINTRODUCTION. Baseline PET/CT imaging parameters for prediction of treatment outcome in Hodgkin and diffuse large B cell lymphoma: A systematic review. Cancer 2005;104:1066-74. https://CRAN.R-project.org/package=psych. Prognostic value of pretransplant FDG-PET in refractory/relapsed Hodgkin lymphoma treated with autologous stem cell transplantation: systematic review and meta-analysis. The .gov means its official. ; Beshir, M.R. Med. Fedorov, A. et al. Informed consent was obtained from all subjects involved in the study. Radiol. Meignan, M.; Gallamini, A.; Meignan, M.; Gallamini, A.; Haioun, C. Report on the First International Workshop on Interim-PET-Scan in Lymphoma. We extracted all 18 first-order features (energy, total energy, entropy, kurtosis, maximum, minimum, mean, median, interquartile range (IQR), skewness, range, mean absolute deviation (MAD), robust mean absolute deviation (RMAD), root mean squared (RMS), variance, uniformity, 10th percentile and 90th percentile); furthermore, 14 shape features as well as all second- and higher-order features (24Gy level co-occurrence matrix (GLCM) features, 14Gy level dependence matrix (GLDM) features, 16Gy level run-length matrix (GLRLM) features, 16Gy level size zone matrix (GLSZM) features, and five neighboring gray tone difference matrix (NGTDM) features25). WebThe blood level of lactate dehydrogenase (LDH), which goes up with the amount of lymphoma in the body Each poor prognostic factor is assigned 1 point. WebLymphoma, T-Cell, Peripheral (1) Radiopharmaceuticals (1) Fluorodeoxyglucose F18 (1) Interv. Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. positive feedback from the reviewers. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. The conventional surgical procedure for lung adenocarcinoma is lobotomy with systematic mediastinal 18F-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is the standard diagnostic test for end-of-treatment assessment in Hodgkin lymphoma1, which accounts for 10% of all diagnosed lymphomas2. Please enable it to take advantage of the complete set of features! Repeatability and reproducibility study of radiomic features on a phantom and human cohort. PET-CT is used for fluorodeoxyglucose-avid lymphoma subtypes, with symptoms alone being used for staging the remaining subtypes. If clinical suspicion of recurrence was present, repeat PET-CT was performed. Rep. 10, 11649. https://doi.org/10.1038/s41598-020-68310-w (2020). Article Blood 132, 22732279. Disclaimer. J. Nucl. PTCLs are heterogeneous in terms of biology, but generally have more aggressive features and poorer outcomes than aggressive B-cell lymphomas when treated with combination chemotherapy.While the best long-term results are still seen with intensive In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by. Swerdlow, A.J. Characteristics. receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. We use cookies on our website to ensure you get the best experience. PET/CT, however, is time-consuming, cost-extensive, linked to high radiation and has a low availability. WebThe Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the Fluorodeoxyglucose (FDG) avidity of a Hodgkins lymphoma or A 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed by a 23-valent pneumococcal polysaccharide vaccine (Pneumovax 23) at least eight weeks later and then again at least five years later, should be administered following lymphoma treatment. [Initial treatment strategy for classical Hodgkin lymphoma in adults]. All Rights Reserved. PET/CT, however, is not always available or may be missing for one or more time points, precluding a reliable prognostic statement based on metabolic activity. Bookshelf WILLIAM D. LEWIS, MD, SETH LILLY, PharmD, BCPS, AND KRISTIN L. JONES, PA-C. Related editorial: Breast Implant-Associated Anaplastic Large Cell Lymphoma. Further classification of distinct lymphoma subtypes is beyond the scope of this article; however, they are ultimately each defined by morphology, immunopheno-type, genetic, molecular, and clinical features.1,3 This article will focus on the types of lymphoma traditionally classified as non-Hodgkin or Hodgkin. 2023. High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). ; software, S.N.N. Berenguer, R. et al. 22, 3539. A PET radiomics model to predict refractory Mediastinal Hodgkin lymphoma. Hodgkin lymphoma is most commonly diagnosed at 20 to 34 years of age; however, the median age at death is 68 because of the higher survival rate among younger patients.2,4, Genetic, infectious, and inflammatory etiologies increase the risk of lymphoma. Research reported in this article was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number 5U54GM104942-03. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. ; Abdelkhalek, E.R. Web8th international workshop on PET in lymphoma and myeloma (PILM 2021) WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Hello I want to change document wide default font. The most common subtype, diffuse large B-cell lymphoma, has a 40% lifetime relapse rate.37 Lifetime relapse in Hodgkin lymphoma occurs in 10% to 15% of patients with early stage disease and 40% of patients with advanced stage disease.38, Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force.39 Complications of lymphoma treatment include secondary malignancies (e.g., breast, lung, skin, colon), cardiac disease, infertility, and endocrine, neurologic, and psychiatric dysfunctions. and L.J.J. We tested all features scanner-wise for their diagnostic performance to evaluate if and which similarities exist between both datasets (single feature diagnostic performance). Classic Hodgkin lymphoma (cHL) includes the following histologic subtypes: nodular sclerosis cHL, lymphocyte-rich cHL, mixed cellularity cHL, and official website and that any information you provide is encrypted PubMed related lymph node density in Hounsfield units in NECT to malignancy in a broad PET/CT study investigating various malignant entities (lung cancer, malignant melanoma, prostate cancer, gastroenteropancreatic neuroendocrine tumors) using different PET-tracers (18F-FDG, 68Ga-DOTATOC, 68Ga-labeled prostate-specific membrane antigen), but without including patients with Hodgkin's disease39. Hodgkin's lymphoma. deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * qPETa quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. The primary end point was the positron emission tomography (PET) response rate after two cycles by expert independent review using the Deauville score. The evaluation was carried out independently by two readers [Reader 1: S.N.N., Reader 2: L.J.J.] FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. Ann Surg Oncol. Image a shows an example slice of a 3D ROI segmenting a lymphoma manifestation in the upper mediastinum. and D.K. Kobe, C. et al. Hussien, A.E. Sci. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. Unauthorized use of these marks is strictly prohibited. "Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?" In particular, international guidelines recommend using the Deauville criteria to assign patients a score of 1 through 5, indicating their response to treatment as Linch DC, Winfield D, Goldstone AH, et al. International validation study for interim PET in ABVD-treated, advanced-stage Hodgkin lymphoma: Interpretation criteria and concordance rate among reviewers. ; et al. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. ; Bartelink, H.; van Leeuwen, F.E. Comprehensive investigation on controlling for ct imaging variabilities in radiomics studies. Patients with lymphoma should have intensive follow-up surveillance for the first two years following remission. ; Hussein, M.H. Bertuzzi, C., Sabattini, E. & Agostinelli, C. Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma. https://doi.org/10.1158/0008-5472.CAN-17-0339 (2017). The readers were required to delineate as much of the target lesion as possible while keeping a minimum distance of 12 pixels from the edge. https://doi.org/10.1038/nrclinonc.2017.141 (2017). FOIA Based on the type of response at interim evaluation, patients showing a complete metabolic R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkins and aggressive non-hodgkins lymphomas. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. ROC curves of these features are presented in Fig. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. MeSH Epub 2013 Nov 15. 32, 30593068. Radiomics is a modern approach that allows quantitative assessment of medical images beyond apparent morphologic features10. WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. Cancer Res. Hosmer Jr, D. W., Lemeshow, S. & Sturdivant, R. X. All authors have read and agreed to the published version of the manuscript. Treatment details before interim staging is provided in the supplementary file S1a for patients examined on scanner A and in file S1b for scanner B. https://doi.org/10.1200/JCO.2013.53.5229 (2014). Rogasch, J. M. et al. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). Le Roux PY, Gastinne T, Le Gouill S, Nowak E, Bodet-Milin C, Querellou S. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri AJ, Vitolo U. Barnes JA, LaCasce AS, Zukotynski K, Israel D, Feng Y, Neuberg D. Sedig LK, Bailey JJ, Wong KK, Brown RK, Kaminski MS, Hutchinson RJ. Increased x-ray attenuation in malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer. Asthana, S.; Labani, S.; Mehrana, S.; Bakhshi, S. Incidence of childhood leukemia and lymphoma in India. Patients should receive a 13-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide vaccine at least eight weeks later with additional age-appropriate vaccinations because lymphoma is an immunosuppressive condition. https://doi.org/10.5152/dir.2015.15220 (2016). Before Ng, A.K. Leuk. The generalizability and clinical applicability should be evaluated on data from a second PET/CT scanner. Laura J. Jensen. Please note that many of the page functionalities won't work as expected without javascript enabled. The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Review Board (or Ethics Committee) of Charit Berlin (protocol code [EA1/104/19] and date of approval [5-14-2019]). 20, 641649. 2023, 13, 445. 1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" Treatment of lymphoma consists of chemotherapy alone or in combination with radiotherapy.24 Radiotherapy alone is not recommended.25 Toxicity from radiotherapy can lead to serious long-term complications such as secondary cancers in the irradiated area, including breast or lung cancers.25 Additionally, patients receiving chemotherapy can subsequently develop breast or lung cancers, melanoma, or acute myeloid leukemia.26,27 Patients who are older than 60 years at diagnosis have worse outcomes, regardless of the staging. 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