Who should not take Metoprolol Succinate? These medications may interact and cause very harmful effects. Metoprolol Succinate ER drug interactions, Email this report to a friend, doctor, or patient. I was prescribed metoprolol succinate 25mg, very low dosage. Usually avoid combinations; use it only under special circumstances. ibuprofen oral decreases effects of metoprolol succinate-hydrochlorothiazide oral by pharmacodynamic antagonism. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Metoprolol and cyclobenzaprine may have additive effects in lowering your blood pressure. Metoprolol and alcohol Drinking alcohol while taking metoprolol is dangerous to your health. Restlessness or edginess. tooth ache & slightly swelling. Metoprolol Succinate ER. Drug class: cardioselective beta blockers, https://www.drugs.com/pro/metoprolol-succinate-er-tablets.html. Blood pressure reducing effects may be reduced. //-->,